"Cardiotonic Steroids and the Sodium Trade Balance: New Insights into Trade-Off Mechanisms Mediated by the Na+/K+-ATPase
FK Khalaf, P Dube, A Mohamed, J Tian, D Malhotra, ST Haller, ...
International journal of molecular sciences 19 (9), 2576 39 2018
Chronic low dose oral exposure to microcystin-LR exacerbates hepatic injury in a murine model of non-alcoholic fatty liver disease
A Lad, RC Su, JD Breidenbach, PM Stemmer, NJ Carruthers, NK Sanchez, ...
Toxins 11 (9), 486 35 2019
Exposure to the harmful algal bloom (HAB) toxin microcystin-LR (MC-LR) prolongs and increases severity of dextran sulfate sodium (DSS)-induced colitis
RC Su, TM Blomquist, AL Kleinhenz, FK Khalaf, P Dube, A Lad, ...
Toxins 11 (6), 371 27 2019
Telocinobufagin, a Novel Cardiotonic Steroid, Promotes Renal Fibrosis via Na+/K+-ATPase Profibrotic Signaling Pathways
DJ Kennedy, FK Khalaf, B Sheehy, ME Weber, B Agatisa-Boyle, J Conic, ...
International journal of molecular sciences 19 (9), 2566 22 2018
Na/K-ATPase/src complex mediates regulation of CD40 in renal parenchyma
JX Xie, S Zhang, X Cui, J Zhang, H Yu, FK Khalaf, D Malhotra, ...
Nephrology Dialysis Transplantation 33 (7), 1138-1149 18 2018
A PON for all seasons: comparing paraoxonase enzyme substrates, activity and action including the role of PON3 in health and disease
CJ Mohammed, S Lamichhane, JA Connolly, SM Soehnlen, FK Khalaf, ...
Antioxidants 11 (3), 590 12 2022
Renal Fibrosis Is Significantly Attenuated Following Targeted Disruption of Cd40 in Experimental Renal Ischemia
S Zhang, JD Breidenbach, FK Khalaf, PR Dube, CJ Mohammed, A Lad, ...
Journal of the American Heart Association 9 (7), e014072 12 2020
Epithelial and Endothelial Adhesion of Immune Cells Is Enhanced by Cardiotonic Steroid Signaling Through Na+/K+‐ATPase‐α‐1
FK Khalaf, I Tassavvor, A Mohamed, Y Chen, D Malhotra, Z Xie, J Tian, ...
Journal of the American Heart Association 9 (3), e013933 10 2020
Microcystin-LR aerosol induces inflammatory responses in healthy human primary airway epithelium
JD Breidenbach, BW French, TT Gordon, AL Kleinhenz, FK Khalaf, ...
Environment International 169, 107531 9 2022
Antioxidant therapy significantly attenuates hepatotoxicity following low dose exposure to microcystin-LR in a murine model of diet-induced non-alcoholic fatty liver disease
A Lad, J Hunyadi, J Connolly, JD Breidenbach, FK Khalaf, P Dube, ...
Antioxidants 11 (8), 1625 9 2022
Proinflammatory effects of cardiotonic steroids mediated by NKA α-1 (Na+/K+-ATPase α-1)/Src complex in renal epithelial cells and immune cells
FK Khalaf, P Dube, AL Kleinhenz, D Malhotra, A Gohara, CA Drummond, ...
Hypertension 74 (1), 73-82 7 2019
Paraoxonase-1 regulation of renal inflammation and fibrosis in chronic kidney disease
FK Khalaf, CJ Mohammed, P Dube, JA Connolly, A Lad, UM Ashraf, ...
Antioxidants 11 (5), 900 5 2022
Microcystin-LR (MC-LR) Triggers Inflammatory Responses in Macrophages
RC Su, JD Breidenbach, K Alganem, FK Khalaf, BW French, P Dube, ...
International Journal of Molecular Sciences 22 (18), 9939 5 2021
Cardioprotective role for paraoxonase-1 in chronic kidney disease
P Dube, FK Khalaf, A DeRiso, CJ Mohammed, JA Connolly, D Battepati, ...
Biomedicines 10 (9), 2301 4 2022
Dirty jobs: macrophages at the heart of cardiovascular disease
TW Stevens, FK Khalaf, S Soehnlen, P Hegde, K Storm, ...
Biomedicines 10 (7), 1579 4 2022
Getting to the heart and soul of chronic kidney disease
FK Khalaf, P Dube, CJ Mohammed, DJ Kennedy
Journal of the American Heart Association 9 (15), e017427 4 2020
Cardiotonic steroid signaling through Na/K-atpase-A-1 and src kinase enhance functional interactions between immune cells and endo/epithelial cells
FK Khalaf, A Mohamed, A Kleinhenz, E Crawford, J Tian, Z Xie, ...
JOURNAL OF INVESTIGATIVE MEDICINE 66 (4), 859-859 2 2018
Cardiotonic steroid signaling through Na/K-ATPase-alpha-1 and Src kinase enhance immune cell pro-inflammatory response
FK Khalaf, AL Kleinhenz, EL Crawford, J Tian, D Malhotra, ST Haller, ...
Circulation 136 (suppl_1), A17625-A17625 2 2017
Paraoxonases at the Heart of Neurological Disorders
FK Khalaf, J Connolly, B Khatib-Shahidi, A Albehadili, I Tassavvor, ...
International Journal of Molecular Sciences 24 (8), 6881 1 2023
Targeted Disruption of Paraoxonase 3 in a Dahl Salt-Sensitive Rat Model of Chronic Kidney Disease Increases Renal Cortical Pro-Inflammatory Eicosanoids
CJ Mohammed, FK Khalaf, P Dube, TJ Reid, JA Connolly, ...
Circulation 142 (Suppl_3), A16835-A16835 1 2020
Paraoxonase 3 is Renoprotective in a Dahl Salt-Sensitive Rat Model of Chronic Kidney Disease
CJ Mohammed, FK Khalaf, P Dube, D Battepati, I Tassavvor, ...
Circulation 140 (Suppl_1), A13721-A13721 1 2019
Novel Model of Oxalate Diet-Induced Chronic Kidney Disease in Dahl-Salt-Sensitive Rats
P Dube, V Aradhyula, A Lad, FK Khalaf, JD Breidenbach, E Kashaboina, ...
International Journal of Molecular Sciences 24 (12), 10062 2023
Oxalate Diet Induced Chronic Kidney Disease in Dahl-Salt-Sensitive Rats Induces Uremic Cardiomyopathy
P Dube
Translation: The University of Toledo Journal of Medical Sciences 11 (1) 2023
EVALUATING THE ROLE OF DIFFERENT TYPES OF LASER THERAPY IN BECKERS NEVUS TREATMENT
P Dube, M Albakaa, M Aldhalimi, F Khalaf
JOURNAL OF INVESTIGATIVE MEDICINE 70 (7), 1576-1576 2022
Evaluating the Roles of Different Types of Laser Therapy in Becker’s Nevus Treatment
MK Al-Bakaa, MA Al-Dhalimi, P Dube, FK Khalaf
Journal of Clinical Medicine 11 (14), 4230 2022
Antioxidant Therapy Ameliorates Hepatotoxicity Induced by Microcystin-LR in an Oleic acid-induced Model of Hep3B Cells Mimicking the Diet-induced Mouse Model of Non-alcoholic …
A Lad, J Breuler, P Hegde, F KHALAF, AL KLEINHENZ, T HINDS, ...
Mechanism of Hepatic Injury Susceptibility and Immune Response to Cyanotoxin … 2021
Antioxidant Therapy Significantly Attenuates Hepatotoxicity Following Low Dose Exposure to Microcystin-LR in a Murine Model of Diet-induced Non-alcoholic Fatty Liver Disease
A Lad, J Hunyadi, FK Khalaf, P Dube, J Connolly, D Baliu-Rodriguez, ...
Mechanism of Hepatic Injury Susceptibility and Immune Response to Cyanotoxin … 2021
Renin-Angiotensin Metabolite Profiling via LC-MS/MS Reveals Sex Dependent Differences Induced by High-Salt Diet in Dahl-S Rats
PR Dube, CJ Mohammed, F Khalaf, S Zhang, D Faleel, S Soehnlen, ...
Circulation 144 (Suppl_1), A13442-A13442 2021
Novel Model of Oxalate Diet Induced Chronic Kidney Disease in Dahl-Salt-Sensitive Rats
P Dube, V Aradhyula, J Connolly, F Khalaf, S Soehnlen, A DeRiso, ...
Circulation 144 (Suppl_1), A12660-A12660 2021
MODULATION OF CARDIOTONIC STEROID ACTIVATION OF NA/K-ATPASE-SRC SIGNALING VIA PNAKTIDE DECREASES CARDIAC INFLAMMATION AND FIBROSIS IN A DAHL SALT SENSITIVE MODEL OF CHRONIC …
P Dube, FK Khalaf, M Patel, A DeRiso, B Khatib-Shahidi, CJ Mohammed, ...
JOURNAL OF INVESTIGATIVE MEDICINE 69 (5), 1079-1079 2021
ANTIOXIDANT THERAPY RESTORES HEPATIC PHASE I & PHASE II METABOLIC ENZYMES ALTERED BY EXPOSURE TO MICROCYSTIN-LR IN A MURINE MODEL OF DIET-INDUCED NON-ALCOHOLIC FATTY LIVER DISEASE
AC Lad, J Hunyadi, J Connolly, FK Khalaf, P Dube, S Zhang, A Kleinhenz, ...
JOURNAL OF INVESTIGATIVE MEDICINE 69 (5), 1140-1141 2021
ACTIVATION OF NA/K-ATPASE SIGNALING BY THE ARACHIDONIC ACID METABOLITE 20-HYDROXYEICOSATETRAENOIC ACID
D Faleel, FK Khalaf, S Zhang, P Dube, D Malhotra, ST Haller, DJ Kennedy
JOURNAL OF INVESTIGATIVE MEDICINE 69 (5), 1124-1124 2021
Paraoxanase-1 Modulates Cardiotonic Steroid Induced Cardiac Inflammation and Fibrosis in Dahl Salt Sensitive Model of Chronic Kidney Disease
PR Dube, F Khalaf, M Patel, B Khatibshahidi, A DeRiso, A Lad, ...
Circulation 142 (Suppl_3), A16965-A16965 2020
PARAOXONASE 1 DELETION LEADS TO INCREASES IN THE PRO-INFLAMMATORY EICOSANOID 20-HETE AS WELL AS RENIN-ANGIOTENSIN SYSTEM ACTIVATION IN A DAHL SALT-SENSITIVE RAT MODEL OF …
FK Khalaf, A Lad, CJ Mohammed, P Dube, JA Connolly, AL Kleinhenz, ...
JOURNAL OF INVESTIGATIVE MEDICINE 68 (5), 1099-1099 2020
HARMFUL ALGAL BLOOM TOXIN MICROCYSTIN-LR EXACERBATES DEXTRAN SULFATE SODIUM INDUCED COLITIS IN A CD40 DEPENDENT MANNER
R Su, A Lad, JD Breidenbach, E Warner, C Meyers, P Dube, FK Khalaf, ...
Journal of Investigative Medicine 68 (5), 1086-1087 2020
Paraoxonase‐1 regulation of Na/K‐ATPase alpha‐1 Src signaling in Chronic Kidney Disease
FK Khalaf, CJ Mohammed, P Dube, J Connolly, A Kleinhenz, D Malhotra, ...
The FASEB Journal 34 (S1), 1-1 2020
Regulation of Renal Inflammation in Chronic Kidney Disease
FK Khalaf
The University of Toledo 2020
Paraoxonase-1 Regulation of Cardiac Inflammation and Fibrosis in Dahl Salt-Sensitive Model of Chronic Kidney Disease
P Dube, F Khalaf, A DeRiso, C Mohammed, D Battepati, AL Kleinhenz, ...
Circulation 140 (Suppl_1), A13852-A13852 2019
CARDIOPROTECTIVE EFFECTS OF PARAOXANASE 3 IN A DAHL SALT-SENSITIVE RAT MODEL OF CHRONIC KIDNEY DISEASE
P Dube, C Mohammed, F Khalaf, A DeRiso, I Tassavvor, D Battepatti, ...
JOURNAL OF INVESTIGATIVE MEDICINE 67 (5), 866-866 2019
TARGETED DISRUPTION OF NA/K-ATPASE-SRC SIGNALING CASCADE SIGNIFICANTLY REDUCES RENAL INFLAMMATION AND OXIDATIVE STRESS FOLLOWING 5/6TH PARTIAL NEPHRECTOMY
FK Khalaf, P Dube, A Kleinhenz, D Malhotra, A Gohara, C Drummond, ...
JOURNAL OF INVESTIGATIVE MEDICINE 67 (5), 920-920 2019
PARAOXANASE 1 DELETION LEADS TO INCREASED CARDIAC REMODELING AND CARDIAC FIBROSIS IN A DAHL SALT-SENSITIVE RAT MODEL OF CHRONIC KIDNEY DISEASE
P Dube, FK Khalaf, C Mohammed, A DeRiso, D Battepatti, T Sarsour, ...
JOURNAL OF INVESTIGATIVE MEDICINE 67 (5), 866-866 2019
Evidence of hepatotoxicity following chronic low dose exposure to microcystin-lr in a murine model of non-alcoholic fatty liver disease
AC Lad, A Spegele, A Kleinhenz, FK Khalaf, S Zhang, R Su, D Malhotra, ...
Journal of Investigative Medicine 66 (4), 824-824 2018
CARDTIOTONIC STEROIDS MEDIATE INFLAMMATION IN RENAL EPITHELIUM VIA THE NA/K-ATPASE ALPHA-1-SRC KINASE SIGNALING PATHWAY
FK Khalaf, J Tian, D Malhotra, Z Xie, D Kennedy
JOURNAL OF INVESTIGATIVE MEDICINE 65 (4), 851-852 2017
Cardiotonic Steroids Promote Renal Fibrosis and Dysfunction via NaK-ATPase Profibrotic Signaling in Heart Failure
X Fan, FK Khalaf, Y Chen, A Guggilam, A Kleinhenz, JB Lingrel, J Tian, ...
Circulation 134 (suppl_1), A17100-A17100"
